Researchers have reported the results of the first randomized clinical trial to test a novel strategy. The approach involves waking up and then killing the ‘sleeping’ HIV that is hiding in the body using an experimental approach known as ‘kick and kill’. Led by Imperial College London , the University of Oxford , MRC Clinical Trials Unit at UCL , and the University of Cambridge , the RIVER study aimed to improve on current care by eradicating HIV from the body, which would represent a major step forward in the search for a cure. The RIVER study, which ran from 2015 to 2018 in London and Brighton, tested the ‘kick and kill’ approach in 60 men recently diagnosed with HIV and who had the virus under control by taking ART. Although investigators found no difference in effect between those participants who received the active ‘kick and kill’ therapy and those who had standard treatment, they say the trial paves the way for testing different combinat...
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